DSP30 enhances the immunosuppressive properties of mesenchymal stromal cells and protects their suppressive potential from lipopolysaccharide effects: A potential role of adenosine.

@article{Sangiorgi2016DSP30ET,
  title={DSP30 enhances the immunosuppressive properties of mesenchymal stromal cells and protects their suppressive potential from lipopolysaccharide effects: A potential role of adenosine.},
  author={Bruno Sangiorgi and Helder Teixeira de Freitas and Josiane Lilian dos Santos Schiavinato and Vitor Le{\~a}o and Rodrigo Haddad and Maristela Delgado Orellana and Vitor Marcel Faça and Germano Aguiar Ferreira and Dimas Tadeu Covas and Marco A. Zago and Rodrigo Alexandre Panepucci},
  journal={Cytotherapy},
  year={2016},
  volume={18 7},
  pages={846-59}
}
Multipotent mesenchymal stromal cells (MSC) are imbued with an immunosuppressive phenotype that extends to several immune system cells. In this study, we evaluated how distinct Toll-like receptor (TLR) agonists impact immunosuppressive properties of bone marrow (BM)-MSC and explored the potential mechanisms involved. We show that TLR4 stimulation by lipopolysaccharide (LPS) restricted the ability of MSC to suppress the proliferation of T lymphocytes, increasing the gene expression of… CONTINUE READING
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