DSC3 expression is regulated by p53, and methylation of DSC3 DNA is a prognostic marker in human colorectal cancer

@inproceedings{Cui2011DSC3EI,
  title={DSC3 expression is regulated by p53, and methylation of DSC3 DNA is a prognostic marker in human colorectal cancer},
  author={Tiantian Cui and Yuan Chen and Linlin Yang and Thomas Kn{\"o}sel and Kristin Z{\"o}ller and Otmar Huber and Iver Petersen},
  booktitle={British Journal of Cancer},
  year={2011}
}
Background:Desmocollin 3 (DSC3), a member of the cadherin superfamily and integral component of desmosomes, is involved in carcinogenesis. However, the role of DSC3 in colorectal cancer (CRC) has not yet been established.Methods:Desmocollin 3 expression in CRC cell lines was analysed by RT–PCR and western blotting. Methylation status of DSC3 was examined by demethylation tests, methylation-specific PCR, and bisulphite sequencing (BS). The regulatory role of p53 was investigated by transfection… CONTINUE READING

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