DSAS-6 Organizes a Tube-like Centriole Precursor, and Its Absence Suggests Modularity in Centriole Assembly

@article{RodriguesMartins2007DSAS6OA,
  title={DSAS-6 Organizes a Tube-like Centriole Precursor, and Its Absence Suggests Modularity in Centriole Assembly},
  author={Ana Rodrigues-Martins and M{\'o}nica Bettencourt-Dias and Maria Riparbelli and Cl{\'a}udia Ferreira and In{\^e}s Ferreira and Giuliano Callaini and David M Glover},
  journal={Current Biology},
  year={2007},
  volume={17},
  pages={1465-1472}
}
Centrioles are microtubule-based cylindrical structures that exhibit 9-fold symmetry and facilitate the organization of centrosomes, flagella, and cilia [1]. Abnormalities in centrosome structure and number occur in many cancers [1, 2]. Despite its importance, very little is known about centriole biogenesis. Recent studies in C. elegans have highlighted a group of molecules necessary for centriole assembly [1, 3]. ZYG-1 kinase recruits a complex of two coiled-coil proteins, SAS-6 and SAS-5… CONTINUE READING
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