DSAS-6 Organizes a Tube-like Centriole Precursor, and Its Absence Suggests Modularity in Centriole Assembly

@article{RodriguesMartins2007DSAS6OA,
  title={DSAS-6 Organizes a Tube-like Centriole Precursor, and Its Absence Suggests Modularity in Centriole Assembly},
  author={A. Rodrigues-Martins and M. Bettencourt-Dias and M. Riparbelli and C. Ferreira and I. Ferreira and G. Callaini and D. Glover},
  journal={Current Biology},
  year={2007},
  volume={17},
  pages={1465-1472}
}
  • A. Rodrigues-Martins, M. Bettencourt-Dias, +4 authors D. Glover
  • Published 2007
  • Medicine, Biology
  • Current Biology
  • Centrioles are microtubule-based cylindrical structures that exhibit 9-fold symmetry and facilitate the organization of centrosomes, flagella, and cilia [1]. Abnormalities in centrosome structure and number occur in many cancers [1, 2]. Despite its importance, very little is known about centriole biogenesis. Recent studies in C. elegans have highlighted a group of molecules necessary for centriole assembly [1, 3]. ZYG-1 kinase recruits a complex of two coiled-coil proteins, SAS-6 and SAS-5… CONTINUE READING
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