Corpus ID: 212607715

DRIED MATRIX SPOTING-AN INNOVATIVE SAMPLE PREPARATION TOOL IN BIOANALYSIS

@inproceedings{Ayre2018DRIEDMS,
  title={DRIED MATRIX SPOTING-AN INNOVATIVE SAMPLE PREPARATION TOOL IN BIOANALYSIS},
  author={Anita P Ayre and Priyanka S. Chaudhari and J. Shaikh and Sachin K Jagdale and Om Prakash Agrawal},
  year={2018}
}
Bioanalysis is a sub-discipline of analytical chemistry covering the quantitative measurement of xenobiotics (drugs and their metabolites and biological molecules in unnatural locations or concentration) and biotics (macromolecules, proteins, DNA, large molecule drugs, metabolites) in biological system. The focus of bioanalysis in the pharmaceutical industry is to provide as quantitative measure of the active drug and/or its metabolite(s) for the purpose of pharmacokinetics, toxicokinetics… Expand
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The two microsampling techniques Dried Blood Spot (DBS) and Volumetric Absorption Microsampling (VAMS) are studied and elaborated in this article with respect to bioanalytical consideration, method validation and regulatory perspectives on its acceptance in regulated bioanalysis. Expand

References

SHOWING 1-10 OF 49 REFERENCES
Dried blood spots: concepts, present status, and future perspectives in bioanalysis.
TLDR
Several advantages of the DBS technique such as low blood volume requirement, transportation and storage without special treatment, better analytes stability, enhanced clinical cooperation in clinical trials, and reduced unforeseeable exposure of analysts to biohazards, make it the most appropriate blood sampling technique. Expand
Quantitation of pregabalin in dried blood spots and dried plasma spots by validated LC-MS/MS methods.
TLDR
Validated methods were applied for the determination of pregabalin levels in dried blood and plasma samples obtained from patients with epilepsy, after per os administration of commercial capsules. Expand
Semi‐quantitative measurement of the antimalarial lumefantrine from untreated dried blood spots using LC–MS/MS
TLDR
Clinical application was demonstrated in exploratory PK–PD analyses of a drug efficacy trial of artemether‐lumefantrine in children with uncomplicated falciparum malaria using post‐treatment day 7 samples, parasite clearance times estimated from serial blood smears, and recurrence of malaria out to 35 days. Expand
Application of dried blood spot cards to determine olive oil phenols (hydroxytyrosol metabolites) in human blood.
TLDR
The proposed method is a significant improvement over existing methods to determine phenolic metabolites circulating in blood and plasma samples, thus making blood sampling possible with the volunteer pricking their own finger, and the subsequent storage of the blood in the DBS cards prior to chromatographic analysis. Expand
Evaluation of plasma microsampling for dried plasma spots (DPS) in quantitative LC-MS/MS bioanalysis using ritonavir as a model compound.
TLDR
The current plasma microsampling for DPS can serve as an alternative to DPS sampling via standard pipetting and wet plasma in in vivo studies. Expand
Bioanalysis of dried saliva spot (DSS) samples using detergent-assisted sample extraction with UHPLC-MS/MS detection.
TLDR
Dried saliva spot (DSS) sampling is a non-invasive sample collection technique for bioanalysis that can be potentially implemented at the patient's home without the need for clinical visits and detergent-assisted extraction with Triton-X-100 could be very useful in DSS or other dried matrix spot (DMS) assays to overcome low or inconsistent analyte recovery issues. Expand
LC–HRMS determination of piperine on rat dried blood spots: A pharmacokinetic study☆
TLDR
The developed and validated liquid chromatography–high resolution mass spectrometry method was successfully applied to pharmacokinetic studies of PPR in rats and exhibited a linear dynamic range over 0.01–2000 ng/mL for PPR on DBS. Expand
A simple dried blood spot method for clinical pharmacological analyses of etoposide in cancer patients using liquid chromatography and fluorescence detection.
TLDR
It can be concluded that the developed and validated DBS method, which is more patient-friendly and requires less sample handling, is a reliable alternative to conventional plasma methods for measuring etoposide concentration in clinical pharmacological analyses. Expand
Development and validation of dried matrix spot sampling for the quantitative determination of amyloid β peptides in cerebrospinal fluid
TLDR
DMS overcame preanalytical problems and allowed the determination of Aβ concentrations that were highly commutable (Bland-Altman) with those obtained using CSF in classical tubes, which should enable the better exploitation of A β analytes for Alzheimer’s diagnosis. Expand
Analysis of metformin, sitagliptin and creatinine in human dried blood spots.
  • M. Scherf-Clavel, P. Högger
  • Medicine, Chemistry
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2015
TLDR
The present study offers a methodological basis for the DBS analysis of metformin and sitagliptin in relation to the patients' creatinine concentration and presents the first evidence that sitgliptin distributes into human blood cells. Expand
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