DRG11 immunohistochemical expression during embryonic development in the mouse.

  title={DRG11 immunohistochemical expression during embryonic development in the mouse.},
  author={Sandra Rebelo and Carlos Reguenga and Liliana Os{\'o}rio and Carlos Alberto de Costa Pereira and Claudia Andr{\'e}ia de Ara{\'u}jo Lopes and Deolinda Lima},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  volume={236 9},
DRG11 is a paired domain transcription factor that is necessary for the assembly of the nociceptive circuitry in the spinal cord dorsal horn. It is expressed in small dorsal root ganglion (DRG) neurons and in their projection area in the spinal cord. Drg11 knockout mice exhibit structural and neurochemical defects both at the DRG and spinal superficial dorsal horn and present reduced nociceptive responses. In this study, a polyclonal antibody against DRG11 was generated and used for a detailed… CONTINUE READING


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