DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites.

@article{Moriguchi2004DREGAD,
  title={DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites.},
  author={Tetsuo Moriguchi and Keiko Haraguchi and Naoko Ueda and Masato Okada and Toshio Furuya and Tetsu Akiyama},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2004},
  volume={9 6},
  pages={
          549-60
        }
}
We have identified and characterized a novel member of the G protein-coupled receptor (GPCR) family, termed DREG. DREG belongs to the LNB-TM7 subfamily and possesses a long amino-terminus that contains a CUB domain, a PTX domain, a hormone binding domain and a GPCR proteolytic site (GPS) domain. RT-PCR experiments and whole mount in situ hybridization in mice showed that DREG is expressed at high levels in the heart and somite during embryogenesis and in the adult lung. When DREG was… CONTINUE READING
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