DRD2 C957T polymorphism interacts with the COMT Val158Met polymorphism in human working memory ability

@article{Xu2007DRD2CP,
  title={DRD2 C957T polymorphism interacts with the COMT Val158Met polymorphism in human working memory ability},
  author={Haiyan Xu and Christoph Kellendonk and Eleanor H Simpson and John George Keilp and T. Conrad Gilliam},
  journal={Schizophrenia Research},
  year={2007},
  volume={90},
  pages={104-107}
}
The C957T polymorphism in the dopamine D2 receptor (DRD2) gene and the Val158Met polymorphism in the Catechol-O-Methyl-Transferase (COMT) gene affect dopamine transmission and have been found to be associated with schizophrenia. Since DRD2 in mice and the COMT gene in humans modulate working memory, we examined the relationship and possible interaction of both polymorphisms to working memory performance in 188 healthy adults. Subjects having the DRD2 C/C allele showed the poorest performance in… CONTINUE READING
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