DRB1*0301 molecules recognize a structural motif distinct from the one recognized by most DR beta 1 alleles.

@article{Sidney1992DRB10301MR,
  title={DRB1*0301 molecules recognize a structural motif distinct from the one recognized by most DR beta 1 alleles.},
  author={John Sidney and Carla Oseroff and Scott Southwood and Melanie Wall and Glenn Y. Ishioka and Frits Koning and Alessandro Sette},
  journal={Journal of immunology},
  year={1992},
  volume={149 8},
  pages={2634-40}
}
The DR3-restricted peptide, MT 65 kDa 3-13, was used to develop a DR3-specific binding assay. The binding activity detected was strictly pH-dependent, in that it was optimal in the pH 4 to 5 range, and no activity was detected at neutral pH. By means of affinity chromatography purifications and the use of DR3-transfected fibroblasts, it was shown that no cross-reactivity exists at the level of DR52a molecules, thus allowing use of only partially purified DR3/DR52a mixtures in high throughput… CONTINUE READING

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