Dipeptidyl peptidase-4 (DPP-4 or CD26) inhibitors, a new class of antidiabetic compounds, are effective in the treatment of hyperglycemia. Because atherosclerosis-related cardiovascular diseases are the major complications of diabetes, it is important to determine the effect of DPP-4 inhibitors on atherosclerosis. In this study, nondiabetic and diabetic… (More)
FIGURE 6. The effect of alogliptin on LPS-stimulated IL-6 secretion by human aortic endothelial cells. Human aortic endothelial cells were treated with or without 10 ng/mL of LPS in the absence or the presence of different concentrations of alogliptin for 24 hours. After the treatment, IL-6 in the culture medium was quantified using the ELISA.