DPP-4 (CD26) inhibitor alogliptin inhibits TLR4-mediated ERK activation and ERK-dependent MMP-1 expression by U937 histiocytes.

@article{Ta2010DPP4I,
  title={DPP-4 (CD26) inhibitor alogliptin inhibits TLR4-mediated ERK activation and ERK-dependent MMP-1 expression by U937 histiocytes.},
  author={Nga N Ta and Yanchun Li and Corinne A. Schuyler and Maria F. Lopes-Virella and Yan Huang},
  journal={Atherosclerosis},
  year={2010},
  volume={213 2},
  pages={
          429-35
        }
}
Dipeptidyl peptidase-4 (DPP-4)/CD26, a cell surface glycoprotein, is expressed by a variety of cells including T cells, B cells, NK cells, and macrophages. Although it has been shown that DPP-4/CD26 is involved in T cell activation, its role in biological functions in macrophages has not been well investigated. In this study, we used alogliptin, a specific inhibitor of DPP 4/CD26, to study the effect of DPP-4/CD26 on the activation of the extracellular signal-regulated kinase (ERK) that plays a… CONTINUE READING
36 Extracted Citations
33 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 36 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 33 references

Similar Papers

Loading similar papers…