DPP‐4 inhibitors and their potential role in the management of type 2 diabetes

@article{Barnett2006DPP4IA,
  title={DPP‐4 inhibitors and their potential role in the management of type 2 diabetes},
  author={Anthony H. Barnett},
  journal={International Journal of Clinical Practice},
  year={2006},
  volume={60}
}
  • A. Barnett
  • Published 2006
  • Medicine
  • International Journal of Clinical Practice
The dipeptidyl peptidase 4 (DPP‐4) inhibitors enhance the body's own ability to control blood glucose by increasing the active levels of incretin hormones in the body. Their mechanism of action is distinct from any existing class of oral glucose‐lowering agents. They control elevated blood glucose by triggering pancreatic insulin secretion, suppressing pancreatic glucagon secretion, and signalling the liver to reduce glucose production. The leading DPP‐4 inhibitors have shown clinically… Expand
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The need for daily injections of potentially immunogenic GLP-1-derived peptides and the potential for unanticipated side effects with chronic use of DPP-IV inhibitors will require ongoing scrutiny of the risk-benefit ratio for these new therapies as they are evaluated in the clinic. Expand
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In patients with type 2 diabetes, near maximal glucose-lowering efficacy of sitagliptin after single oral doses was associated with inhibition of plasma DPP-4 activity of 80% or greater, corresponding to a plasma sitgliptin concentration of 100 nm or greater and an augmentation of active GLP-1 and GIP levels of 2-fold or higher after an OGTT. Expand
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