DPC4/Smad4 expression and outcome in pancreatic ductal adenocarcinoma.

@article{Biankin2002DPC4Smad4EA,
  title={DPC4/Smad4 expression and outcome in pancreatic ductal adenocarcinoma.},
  author={Andrew V. Biankin and Adrienne L. Morey and Croonian Lee and James G Kench and Sandra A. Biankin and Henry C Hook and Darren R. Head and Thomas Hugh and Robert Lyndsay Sutherland and Susan M. Henshall},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2002},
  volume={20 23},
  pages={
          4531-42
        }
}
PURPOSE Prognostic indicators in pancreatic cancer (PC) are poorly defined and difficult to quantify preoperatively, hence they may lead to inappropriate patient selection for treatment. We examined the protein expression of key cell-cycle regulatory and cell-signaling molecules that occur at high frequency in PC and assessed their relationship to clinicopathologic parameters, response to operative resection, and outcome. PATIENTS AND METHODS We identified 348 patients with pancreatic ductal… CONTINUE READING
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