DOTAGA-anhydride: a valuable building block for the preparation of DOTA-like chelating agents.

@article{Bernhard2012DOTAGAanhydrideAV,
  title={DOTAGA-anhydride: a valuable building block for the preparation of DOTA-like chelating agents.},
  author={Claire Bernhard and Mathieu Moreau and Damien Lhenry and Christine Goze and Fr{\'e}d{\'e}ric Boschetti and Yoann Rousselin and François Brunotte and Franck Denat},
  journal={Chemistry},
  year={2012},
  volume={18 25},
  pages={
          7834-41
        }
}
  • Claire Bernhard, Mathieu Moreau, +5 authors Franck Denat
  • Published in Chemistry 2012
  • Medicine, Chemistry
  • A DOTA derivative that contains an anhydride group was readily synthesized by reacting DOTAGA with acetic anhydride and its reactivity was investigated. Opening the anhydride with propylamine led to the selective formation of one of two possible regioisomers. The structure of the obtained isomer was unambiguously determined by 1D and 2D NMR experiments, including COSY, HMBC, and NOESY techniques. This bifunctional chelating agent offers a convenient and attractive approach for labeling… CONTINUE READING

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