DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells.

@article{Steger2008DOT1LKMT4RA,
  title={DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells.},
  author={David J Steger and Martina I. Lefterova and Lei Ying and Aaron J Stonestrom and Michael Schupp and David Zhuo and Adam L Vakoc and J T Kim and Junjie Chen and Mitchell A Lazar and Gerd A Blobel and Christopher R Vakoc},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 8},
  pages={2825-39}
}
The histone H3 lysine 79 methyltransferase DOT1L/KMT4 can promote an oncogenic pattern of gene expression through binding with several MLL fusion partners found in acute leukemia. However, the normal function of DOT1L in mammalian gene regulation is poorly understood. Here we report that DOT1L recruitment is ubiquitously coupled with active transcription in diverse mammalian cell types. DOT1L preferentially occupies the proximal transcribed region of active genes, correlating with enrichment of… CONTINUE READING

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