DOG1: a novel marker of salivary acinar and intercalated duct differentiation

  title={DOG1: a novel marker of salivary acinar and intercalated duct differentiation},
  author={Jacinthe Ch{\^e}nevert and Umamaheswar Duvvuri and Simion I Chiosea and Sanja Dacic and Kathleen M. Cieply and Jean Kim and Daniel J Shiwarski and Raja R Seethala},
  journal={Modern Pathology},
Anoctamin-1 (ANO1) (DOG1, TMEM16a) is a calcium-activated chloride channel initially described in gastrointestinal stromal tumors, but now known to be expressed in a variety of normal and tumor tissues including salivary tissue in murine models. We herein perform a comprehensive survey of DOG1 expression in 156 cases containing non-neoplastic human salivary tissues and tumors. ANO1 mRNA levels were significantly higher (8-fold increase, P<0.0001) in normal parotid tissue (n=6) as compared with… CONTINUE READING
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Physiology (Bethesda) 2010;25:357–363

  • DG Hwang, X Qian, JL. Hornick
  • 2010

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