DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

@inproceedings{Randall2011DOCK8DI,
  title={DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice},
  author={Katrina L Randall and Stephanie S.-Y. Chan and Cindy S Ma and Ivan Fung and Yan Mei and Mehmet Yabas and Andy H-M Tan and Peter D Arkwright and Wafaa Al Suwairi and Saul Oswaldo Lugo Reyes and Marco Yamazaki-Nakashimada and Maria de la Luz Garcia-Cruz and Joanne M. Smart and Capucine Picard and Satoshi Okada and Emmanuelle Jouanguy and J. Hugo P{\'e}rez Casanova and Teresa Lambe and Richard J. Cornall and Sarah Russell and Jane Oliaro and Stuart G Tangye and Edward M. Bertram and Christopher C. Goodnow},
  booktitle={The Journal of experimental medicine},
  year={2011}
}
In humans, DOCK8 immunodeficiency syndrome is characterized by severe cutaneous viral infections. Thus, CD8 T cell function may be compromised in the absence of DOCK8. In this study, by analyzing mutant mice and humans, we demonstrate a critical, intrinsic role for DOCK8 in peripheral CD8 T cell survival and function. DOCK8 mutation selectively diminished the abundance of circulating naive CD8 T cells in both species, and in DOCK8-deficient humans, most CD8 T cells displayed an exhausted CD45RA… CONTINUE READING