DOCK2 is required in T cell precursors for development of Valpha14 NK T cells.

@article{Kunisaki2006DOCK2IR,
  title={DOCK2 is required in T cell precursors for development of Valpha14 NK T cells.},
  author={Yuya Kunisaki and Yoshihiko Tanaka and Terukazu Sanui and Ayumi Inayoshi and Mayuko Noda and Toshinori Nakayama and Michishige Harada and Masaru Taniguchi and Takehiko Sasazuki and Yoshinori Fukui},
  journal={Journal of immunology},
  year={2006},
  volume={176 8},
  pages={4640-5}
}
Mouse CD1d-restricted Valpha14 NKT cells are a unique subset of lymphocytes, which play important roles in immune regulation, tumor surveillance and host defense against pathogens. DOCK2, a mammalian homolog of Caenorhabditis elegans CED-5 and Drosophila melanogaster myoblast city, is critical for lymphocyte migration and regulates T cell responsiveness through immunological synapse formation, yet its role in Valpha14 NKT cells remains unknown. We found that DOCK2 deficiency causes marked… CONTINUE READING
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