DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4.

Abstract

RATIONALE During embryogenesis, the CXC chemokine ligand (CXCL)12 acts on endothelial cells to control cardiac development and angiogenesis. Although biological functions of CXCL12 are exerted in part through activation of the small GTPase Rac, the pathway leading from its receptor CXC chemokine receptor (CXCR)4 to Rac activation remains to be determined… (More)
DOI: 10.1161/CIRCRESAHA.110.223388

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