Corpus ID: 39935523

DNpro: A Deep Learning Network Approach to Predicting Protein Stability Changes Induced by Single-Site Mutations

  title={DNpro: A Deep Learning Network Approach to Predicting Protein Stability Changes Induced by Single-Site Mutations},
  author={Xiaoping Zhou and Jianlin Cheng},
  journal={World Academy of Science, Engineering and Technology, International Journal of Bioengineering and Life Sciences},
  • Xiaoping Zhou, Jianlin Cheng
  • Published 2016
  • Computer Science
  • World Academy of Science, Engineering and Technology, International Journal of Bioengineering and Life Sciences
A single amino acid mutation can have a significant impact on the stability of protein structure. Thus, the prediction of protein stability change induced by single site mutations is critical and useful for studying protein function and structure. Here, we presented a new deep learning network with the dropout technique for predicting protein stability changes upon single amino acid substitution. While using only protein sequence as input, the overall prediction accuracy of the method on a… Expand

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