DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression.

@article{Fraser1990DNaseIHS,
  title={DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression.},
  author={Paul Fraser and Jane Hurst and Philip S. Collis and Frank Grosveld},
  journal={Nucleic acids research},
  year={1990},
  volume={18 12},
  pages={3503-8}
}
The human beta-globin dominant control region (DCR) which flanks the multigene beta-globin locus directs high level, site of integration independent, copy number dependent expression on a linked human beta-globin gene in transgenic mice and stably transfected mouse erythroleukemia (MEL) cells. We have assayed each of the individual DNaseI hypersensitive regions present in the full 15kb DCR for position independence and copy number dependence of a linked beta-globin gene in transgenic mice. The… CONTINUE READING