DNase1L2 suppresses biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus.

@article{Eckhart2007DNase1L2SB,
  title={DNase1L2 suppresses biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus.},
  author={Leopold Eckhart and Heinz Fischer and Kim Bundvig Barken and Tim Tolker-Nielsen and Erwin Tschachler},
  journal={The British journal of dermatology},
  year={2007},
  volume={156 6},
  pages={1342-5}
}
BACKGROUND The formation of biofilms, which is an important step in bacterial colonization, can be inhibited by deoxyribonuclease (DNase)-mediated breakdown of extracellular DNA. We have recently demonstrated that epidermal keratinocytes strongly express DNase1-like 2 (DNase1L2) in a differentiation-associated manner. OBJECTIVES To determine whether enzymatically active DNase1L2 is present in human stratum corneum and whether it is able to suppress bacterial biofilm formation. METHODS… CONTINUE READING

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