DNase II and the Chk2 DNA damage pathway form a genetic barrier blocking replication of horizontally transferred DNA.

@article{Bergsmedh2006DNaseIA,
  title={DNase II and the Chk2 DNA damage pathway form a genetic barrier blocking replication of horizontally transferred DNA.},
  author={Anna Bergsmedh and Jacob Ehnfors and Kohki Kawane and Noboru Motoyama and Shigekazu Nagata and Lars Holmgren},
  journal={Molecular cancer research : MCR},
  year={2006},
  volume={4 3},
  pages={187-95}
}
We have previously shown that DNA from dying tumor cells may be transferred to living cells via the uptake of apoptotic bodies and may contribute to tumor progression. DNA encoding H-ras(V12) and c-myc oncogenes may be transferred to the nucleus of the phagocyte but will only integrate and propagate in p53- and p21-deficient mouse embryonic fibroblasts… CONTINUE READING