DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells

@article{Robert2003DNMT1IR,
  title={DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells},
  author={M. F. Robert and Steves Morin and Normand Beaulieu and France Gauthier and Ian C Chute and Annie Barsalou and A. Robert Macleod},
  journal={Nature Genetics},
  year={2003},
  volume={33},
  pages={61-65}
}
Transcriptional silencing by CpG island methylation is a prevalent mechanism of tumor-suppressor gene suppression in cancers. Genetic experiments have defined the importance of the DNA methyltransferase Dnmt1 for the maintenance of methylation in mouse cells and its role in neoplasia. In human bladder cancer cells, selective depletion of DNMT1 with antisense inhibitors has been shown to induce demethylation and reactivation of the silenced tumor-suppressor gene CDKN2A. In contrast, targeted… 
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