DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

@article{Robertson2000DNMT1FA,
  title={DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters},
  author={Keith D. Robertson and Slimane Ait-Si-Ali and Tomoki Yokochi and Paul A. Wade and Peter L Jones and Alan P. Wolffe},
  journal={Nature Genetics},
  year={2000},
  volume={25},
  pages={338-342}
}
Methylation of CpG islands is associated with transcriptional silencing and the formation of nuclease-resistant chromatin structures enriched in hypoacetylated histones. Methyl-CpG-binding proteins, such as MeCP2, provide a link between methylated DNA and hypoacetylated histones by recruiting histone deacetylase, but the mechanisms establishing the methylation patterns themselves are unknown. Whether DNA methylation is always causal for the assembly of repressive chromatin or whether features… Expand
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