DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

@article{Rountree2000DNMT1BH,
  title={DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci},
  author={M. R. Rountree and K. Bachman and S. Baylin},
  journal={Nature Genetics},
  year={2000},
  volume={25},
  pages={269-277}
}
DNA methylation can contribute to transcriptional silencing through several transcriptionally repressive complexes, which include methyl-CpG binding domain proteins (MBDs) and histone deacetylases (HDACs). We show here that the chief enzyme that maintains mammalian DNA methylation, DNMT1, can also establish a repressive transcription complex. The non-catalytic amino terminus of DNMT1 binds to HDAC2 and a new protein, DMAP1 (for DNMT1 associated protein), and can mediate transcriptional… Expand
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