DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer

  title={DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer},
  author={Olufunmilade Akinfolarin Omisanjo and Katharina Biermann and Sonja Hartmann and Lukas Heukamp and Violetta Sonnack and Anne Hild and Ralph Brehm and Martin W Bergmann and Wolfgang Weidner and Klaus Steger},
  journal={Histochemistry and Cell Biology},
DNA methylation catalyzed by DNA methyltransferases (DNMTs) and histone deacetylation catalyzed by histone deacetylases (HDACs) play an important role for the regulation of gene expression during carcinogenesis and spermatogenesis. We therefore studied the cell-specific expression of DNMT1 and HDAC1 for the first time in human testicular cancer and impaired human spermatogenesis. During normal spermatogenesis, DNMT1 and HDAC1 were colocalized in nuclei of spermatogonia. While HDAC1 was… CONTINUE READING


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Early molecular events in precursor lesions and testicular germ cell tumors

  • K Biermann, LC Heukamp, +9 authors R Büttner
  • J Pathol (in press)
  • 2006
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