DNMT1 ablation suppresses tumorigenesis by inhibiting the self-renewal of esophageal cancer stem cells

  title={DNMT1 ablation suppresses tumorigenesis by inhibiting the self-renewal of esophageal cancer stem cells},
  author={Y. Teng and Xiying Yu and H. Yuan and L. Guo and W. Jiang and S. Lu},
  pages={18896 - 18907}
  • Y. Teng, Xiying Yu, +3 authors S. Lu
  • Published 2018
  • Medicine
  • Oncotarget
  • Cancer stem cells (CSCs) have been isolated from many tumors and considered as the main reason of cancer recurrence and metastasis. DNA methyltransferase 1 (DNMT1) mediates DNA methylation and plays an important role in CSCs maintenance. However, the function of DNMT1 in CSCs of esophageal squamous cell carcinoma (ESCC) remains unclear. In this study, we examined the role of DNMT1 in regulating self-renewal in CSCs of ESCC. We found a high expression of DNMT1 in both side population (SP) cells… CONTINUE READING
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