DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs

Abstract

The vertebrate-conserved RNA-binding protein DND1 is required for the survival of primordial germ cells (PGCs), as well as the suppression of germ cell tumours in mice. Here we show that in mice DND1 binds a UU(A/U) trinucleotide motif predominantly in the 3' untranslated regions of mRNA, and destabilizes target mRNAs through direct recruitment of the CCR4… (More)
DOI: 10.1038/nature21690

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Cite this paper

@inproceedings{Yamaji2017DND1MG, title={DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs}, author={Masashi Yamaji and Miki Jishage and Cindy Meyer and Hemant Suryawanshi and Evan Der and Misaki Yamaji and Aitor Garzia and Pavel Morozov and Sudhir Manickavel and Hannah L. McFarland and Robert G Roeder and Markus Hafner and Thomas Tuschl}, booktitle={Nature}, year={2017} }