• Corpus ID: 2825647

DNAbling Protein Partners

  title={DNAbling Protein Partners},
  author={Eva J. Gordon},
The proteasome, the multiprotein complex that is responsible for a large portion of protein degradation in the cell, has captured the interest of scientists from diverse areas, including evolutionary biology, the biochemistry of proteolysis, and drug discovery. Indeed, the recent approval of the proteasome inhibitor bortezomib for the treatment of multiple myeloma underscores the value of understanding the structure and function of this extraordinary protease. Activity-based inhibitors that…