DNAPKcs-dependent arrest of RNA polymerase II transcription in the presence of DNA breaks

  title={DNAPKcs-dependent arrest of RNA polymerase II transcription in the presence of DNA breaks},
  author={T Pankotai and C{\'e}line Bonhomme and David J. Chen and Evi Soutoglou},
  journal={Nature Structural &Molecular Biology},
DNA double-strand break (DSB) repair interferes with ongoing cellular processes, including replication and transcription. Although the process of replication stalling upon collision of replication forks with damaged DNA has been extensively studied, the fate of elongating RNA polymerase II (RNAPII) that encounters a DSB is not well understood. We show that the occurrence of a single DSB at a human RNAPII-transcribed gene leads to inhibition of transcription elongation and reinitiation. Upon… CONTINUE READING
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