DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes.

  title={DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes.},
  author={Akira Shibuya and Debbie Campbell and Charles Hannum and Hans Yssel and Karin Franz-Bacon and Terri Mcclanahan and Tadahiro Kitamura and J. Ross Nicholl and Grant R. Sutherland and Lewis L. Lanier and Joseph H. Phillips},
  volume={4 6},
Intercellular adhesion molecules play an important role in the generation of T lymphocyte-mediated immune responses. Here, we describe a novel accessory molecule, DNAX accessory molecule-1 (DNAM-1), that is constitutively expressed on the majority of peripheral blood T lymphocytes. DNAM-1 is a 65 kDa transmembrane glycoprotein consisting of 318 aa including two immunoglobulin-like domains. Anti-DNAM-1 monoclonal antibody (MAb) inhibits T and NK cell-mediated cytotoxicity against a variety of… CONTINUE READING
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