DNAJB3/HSP-40 Cochaperone Is Downregulated in Obese Humans and Is Restored by Physical Exercise

  title={DNAJB3/HSP-40 Cochaperone Is Downregulated in Obese Humans and Is Restored by Physical Exercise},
  author={Jehad Abubaker and Ali Tiss and Mohamed Abu-Farha and Fahad A Al-Ghimlas and Irina Al-Khairi and Engin Baturcam and Preethi Cherian and Nasser B Elkum and Maha Hammad and Jeena John and Sina Kavalakatt and Abdelkrim Khadir and Samia Warsame and Said Dermime and Kazem Behbehani and Mohammed Dehbi},
  booktitle={PloS one},
Obesity is a major risk factor for a myriad of disorders such as insulin resistance and diabetes. The mechanisms underlying these chronic conditions are complex but low grade inflammation and alteration of the endogenous stress defense system are well established. Previous studies indicated that impairment of HSP-25 and HSP-72 was linked to obesity, insulin resistance and diabetes in humans and animals while their induction was associated with improved clinical outcomes. In an attempt to… CONTINUE READING
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