DNAJB1-PRKACA is specific for fibrolamellar carcinoma

  title={DNAJB1-PRKACA is specific for fibrolamellar carcinoma},
  author={Rondell P Graham and Long Jin and Darlene L Knutson and Sara M Kloft-Nelson and Patricia T Greipp and Nina Waldburger and Stephanie Roessler and Thomas Longerich and Lewis R. Roberts and Andr{\'e} Luiz Malavasi Longo de Oliveira and Kevin C. Halling and Peter Schirmacher and Michael S. Torbenson},
  journal={Modern Pathology},
Fibrolamellar carcinoma is a distinct subtype of hepatocellular carcinoma that predominantly affects young patients without underlying cirrhosis. A recurrent DNAJB1-PRKACA fusion has recently been reported in fibrolamellar carcinomas. To determine the specificity of this fusion and to develop routinely available clinical methods of detection, we developed an RT-PCR assay for paraffin-embedded tissues and a FISH probe for detection of the rearrangements of the PRKACA locus. We also developed an… CONTINUE READING
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