DNAJB1-PRKACA is specific for fibrolamellar carcinoma

@article{Graham2015DNAJB1PRKACAIS,
  title={DNAJB1-PRKACA is specific for fibrolamellar carcinoma},
  author={Rondell P Graham and Long Jin and Darlene L Knutson and Sara M Kloft-Nelson and Patricia T Greipp and Nina Waldburger and Stephanie Roessler and Thomas Longerich and Lewis R. Roberts and Andr{\'e} Luiz Malavasi Longo de Oliveira and Kevin C. Halling and Peter Schirmacher and Michael S. Torbenson},
  journal={Modern Pathology},
  year={2015},
  volume={28},
  pages={822-829}
}
Fibrolamellar carcinoma is a distinct subtype of hepatocellular carcinoma that predominantly affects young patients without underlying cirrhosis. A recurrent DNAJB1-PRKACA fusion has recently been reported in fibrolamellar carcinomas. To determine the specificity of this fusion and to develop routinely available clinical methods of detection, we developed an RT-PCR assay for paraffin-embedded tissues and a FISH probe for detection of the rearrangements of the PRKACA locus. We also developed an… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 101 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 65 references

Cancer Genome Atlas Research Network Integrated genomic characterization of papillary thyroid carcinoma

  • CT Huang, YJ Oyang, HC Huang
  • Cell
  • 2014

Constitutive activation of PKA catalytic subunit in adrenal Cushing ’ s syndrome

  • Y Cao, M He, Z Gao
  • N Engl J Med
  • 2014

Fibroblast growth factor receptor 2 translocations in intrahepatic cholangiocarcinoma

  • RP Graham, EG BarrFritcher, E Pestova
  • Hum Pathol
  • 2014

Similar Papers

Loading similar papers…