DNA vector constructs that prime hepatitis B surface antigen-specific cytotoxic T lymphocyte and antibody responses in mice after intramuscular injection.

@article{Bhm1996DNAVC,
  title={DNA vector constructs that prime hepatitis B surface antigen-specific cytotoxic T lymphocyte and antibody responses in mice after intramuscular injection.},
  author={W. B{\"o}hm and A. Kuhr{\"o}ber and T Paier and Thomas Mertens and J. Reimann and R. Schirmbeck},
  journal={Journal of immunological methods},
  year={1996},
  volume={193 1},
  pages={29-40}
}
We tested the efficiency of induction of immune responses to the small hepatitis B surface antigen (HBsAg) in mice by intramuscular DNA immunization using different vector constructs that allow high levels of HBsAg expression in mouse cells. The HBsAg-specific responses of class I-restricted cytotoxic T lymphocytes (CTL) and of B cells (serum antibody titers) were measured. Following the intramuscular inoculation of 'naked' DNA, five different vector constructs of 4-8 kb, that contained or did… CONTINUE READING