DNA vaccines expressing either the GP or NP genes of Ebola virus protect mice from lethal challenge.

@article{Vanderzanden1998DNAVE,
  title={DNA vaccines expressing either the GP or NP genes of Ebola virus protect mice from lethal challenge.},
  author={Lorna Vanderzanden and Mike Bray and Dan Fuller and Timothy Roberts and David M Custer and Kristin W. Spik and Peter B Jahrling and John Huggins and Alan L. Schmaljohn and Connie S. Schmaljohn},
  journal={Virology},
  year={1998},
  volume={246 1},
  pages={
          134-44
        }
}
DNA vaccines expressing the envelope glycoprotein (GP) or nucleocapsid protein (NP) genes of Ebola virus were evaluated in adult, immunocompetent mice. The vaccines were delivered into the skin by particle bombardment of DNA-coated gold beads with the Powderject-XR gene gun. Both vaccines elicited antibody responses as measured by ELISA and elicited cytotoxic T cell responses as measured by chromium release assays. From one to four vaccinations with 0.5 microgram of the GP DNA vaccine resulted… CONTINUE READING
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