DNA vaccines expressing different forms of simian immunodeficiency virus antigens decrease viremia upon SIVmac251 challenge.

@article{Rosati2005DNAVE,
  title={DNA vaccines expressing different forms of simian immunodeficiency virus antigens decrease viremia upon SIVmac251 challenge.},
  author={Margherita Rosati and Agneta von Gegerfelt and Patricia A. Roth and Candido Alicea and Antonio Valent{\'i}n and Marjorie Robert-Guroff and David J Venzon and David C. Montefiori and Phil Markham and Barbara K Felber and George N Pavlakis},
  journal={Journal of virology},
  year={2005},
  volume={79 13},
  pages={8480-92}
}
We have tested the efficacy of DNA immunization as a single vaccination modality for rhesus macaques followed by highly pathogenic SIVmac251 challenge. To further improve immunogenicity of the native proteins, we generated expression vectors producing fusion of the proteins Gag and Env to the secreted chemokine MCP3, targeting the viral proteins to the secretory pathway and to a beta-catenin (CATE) peptide, targeting the viral proteins to the intracellular degradation pathway. Macaques… CONTINUE READING

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