DNA vaccines expressing antigens with a stress protein-capturing domain display enhanced immunogenicity.

@article{Reimann2004DNAVE,
  title={DNA vaccines expressing antigens with a stress protein-capturing domain display enhanced immunogenicity.},
  author={J. Reimann and R. Schirmbeck},
  journal={Immunological reviews},
  year={2004},
  volume={199},
  pages={54-67}
}
An expression system for DNA vaccines is described, in which a fusion protein with an N-terminal, viral J-domain that captures heat-shock proteins (Hsps) is translated in-frame with C-terminal antigen-encoding sequences (of various lengths and origins). The system supports enhanced expression of chimeric antigens (of >800 residues in length) with an extended half life (>8 h). When used as a DNA vaccine, it delivers antigen together with the intrinsic adjuvant activity provided by bound Hsps. We… CONTINUE READING

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