DNA vaccines as a tool for analysing the protective immune response against rhabdoviruses in rainbow trout.

@article{Lorenzen2002DNAVA,
  title={DNA vaccines as a tool for analysing the protective immune response against rhabdoviruses in rainbow trout.},
  author={Niels Lorenzen and Ellen Lorenzen and Katja Einer-Jensen and Scott E. Lapatra},
  journal={Fish & shellfish immunology},
  year={2002},
  volume={12 5},
  pages={439-53}
}
DNA vaccines based on the glycoprotein genes of the salmonid rhabdoviruses VHSV and IHNV have been demonstrated to be very efficient in inducing a protective immune response against the respective diseases in rainbow trout. Nanogram doses of plasmid DNA delivered by intramuscular injection are sufficient to induce high levels of immunity in fingerling-size fish, whereas larger fish require more vaccine for protection. The protection is long lasting and, more surprisingly, is partly established… CONTINUE READING

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