DNA vaccine of SARS-Cov S gene induces antibody response in mice.

  title={DNA vaccine of SARS-Cov S gene induces antibody response in mice.},
  author={Ping Zhao and Jin-shan Ke and Zhao-Lin Qin and H. C. Ren and Lan-Juan Zhao and Jian-guo Yu and Jun Gao and Shi-ying Zhu and Zhong-tian Qi},
  journal={Acta biochimica et biophysica Sinica},
  volume={36 1},
The spike (S) protein, a main surface antigen of SARS-coronavirus (SARS-CoV), is one of the most important antigen candidates for vaccine design. In the present study, three fragments of the truncated S protein were expressed in E.coli, and analyzed with pooled sera of convalescence phase of SARS patients. The full length S gene DNA vaccine was constructed and used to immunize BALB/c mice. The mouse serum IgG antibody against SARS-CoV was measured by ELISA with E. coli expressed truncated S… CONTINUE READING


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