DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response.

@article{Mimran2004DNAVW,
  title={DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response.},
  author={Avishai Mimran and Felix Mor and Pnina Carmi and Francisco J. Quintana and Varda Rotter and Irun R. Cohen},
  journal={The Journal of clinical investigation},
  year={2004},
  volume={113 6},
  pages={924-32}
}
Ab's to the alpha-chain of the IL-2 receptor (anti-CD25) are used clinically to achieve immunosuppression. Here we investigated the effects of DNA vaccination with the whole CD25 gene on the induction of rat adjuvant arthritis. The DNA vaccine protected the rats and led to a shift in the cytokine profile of T cells responding to disease target antigens from Th1 to Th2. The mechanism of protection was found to involve the induction of an antiergotypic response, rather than the induction of anti… CONTINUE READING
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