DNA vaccination in the skin using microneedles improves protection against influenza.

@article{Song2012DNAVI,
  title={DNA vaccination in the skin using microneedles improves protection against influenza.},
  author={Jae-Min Song and Yeu-Chun Kim and O Eunju and Richard W. Compans and Mark R. Prausnitz and Sang-Moo Kang},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2012},
  volume={20 7},
  pages={1472-80}
}
In this study, we tested the hypothesis that DNA vaccination in the skin using microneedles improves protective immunity compared to conventional intramuscular (i.m.) injection of a plasmid DNA vaccine encoding the influenza hemagglutinin (HA). In vivo fluorescence imaging demonstrated the expression of a reporter gene delivered to the skin using a solid microneedle patch coated with plasmid DNA. Vaccination at a low dose (3 µg HA DNA) using microneedles generated significantly stronger humoral… CONTINUE READING
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