DNA vaccination controls Her-2+ tumors that are refractory to targeted therapies.

  title={DNA vaccination controls Her-2+ tumors that are refractory to targeted therapies.},
  author={Paula J. Whittington and Marie P. Piechocki and Henry H Heng and Jennifer B. Jacob and Richard F. Jones and Jessica B. Back and Wei Wei},
  journal={Cancer research},
  volume={68 18},
Her-2/neu(+) tumor cells refractory to antibody or receptor tyrosine kinase inhibitors are emerging in treated patients. To investigate if drug resistant tumors can be controlled by active vaccination, gefitinib and antibody sensitivity of four neu(+) BALB/c mouse mammary tumor lines were compared. Significant differences in cell proliferation and Akt phosphorylation were observed. Treatment-induced drug resistance was associated with increased chromosomal aberrations as shown by spectral… CONTINUE READING


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Stochastic cancer Research. on May 10, 2017

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1 Excerpt

progression driven by nonclonal chromosome aberrations

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