DNA unwinding and protein displacement by superfamily 1 and superfamily 2 helicases

@article{Mackintosh2006DNAUA,
  title={DNA unwinding and protein displacement by superfamily 1 and superfamily 2 helicases},
  author={Samuel G. Mackintosh and Kevin D. Raney},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={4154 - 4159}
}
DNA helicases are required for virtually every aspect of DNA metabolism, including replication, repair, recombination and transcription. A comprehensive description of these essential biochemical processes requires detailed understanding of helicase mechanisms. These enzymes are ubiquitous, having been identified in viruses, prokaryotes and eukaryotes. Disease states, such as xeroderma pigmentosum, Cockayne's syndrome, Bloom's syndrome and Werner's syndrome, have been linked to defects in… CONTINUE READING