DNA translocation by human uracil DNA glycosylase: role of DNA phosphate charge.

@article{Schonhoft2013DNATB,
  title={DNA translocation by human uracil DNA glycosylase: role of DNA phosphate charge.},
  author={Joseph D. Schonhoft and John G Kosowicz and James T Stivers},
  journal={Biochemistry},
  year={2013},
  volume={52 15},
  pages={2526-35}
}
Human DNA repair glycosylases must encounter and inspect each DNA base in the genome to discover damaged bases that may be present at a density of <1 in 10 million normal base pairs. This remarkable example of specific molecular recognition requires a reduced dimensionality search process (facilitated diffusion) that involves both hopping and sliding along… CONTINUE READING