DNA transitions induced by binding of PARP-1 to cruciform structures in supercoiled plasmids.


BACKGROUND Poly(ADP-ribose)polymerase-1 (PARP-1) binds to single and double-stranded breaks in DNA, but less well known is its affinity for undamaged DNA. Previously, we have shown that PARP-1 also binds to the hairpin structures in DNA models. The mechanism underlying these interactions remains to be defined. METHODS We analyzed atomic force microscopy… (More)


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