DNA topological stress during DNA replication in Saccharomyces cerevisiae

@inproceedings{Minchell2019DNATS,
  title={DNA topological stress during DNA replication in Saccharomyces cerevisiae},
  author={Nicola E. Minchell},
  year={2019}
}
DNA topological stress impedes normal DNA replication. If topological stress is allowed to build up in front of the replication fork, the fork rotates to overcome the stress, leading to formation of DNA pre-catenanes. The formation of DNA pre-catenanes is therefore a marker of DNA topological stress. In this study, I have examined how transcription linked DNA topological stress impacts on fork rotation and on endogenous DNA damage. Transcription, similar to replication, affects the topology of… CONTINUE READING

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