DNA topoisomerases from pathogenic fungi: targets for the discovery of antifungal drugs.

@article{Shen1992DNATF,
  title={DNA topoisomerases from pathogenic fungi: targets for the discovery of antifungal drugs.},
  author={Linus L Shen and Jacek Baranowski and J M Fostel and D. A. D. Montgomery and Paul Lartey},
  journal={Antimicrobial agents and chemotherapy},
  year={1992},
  volume={36 12},
  pages={2778-84}
}
DNA topoisomerases, a class of enzymes that change the topological structure of DNA, have been shown to be the target of many therapeutic agents, including antibacterial agents (quinolones) and anticancer agents. These drugs inhibit the enzyme in a unique way so that the enzyme is converted into a cellular poison. Candida albicans and Aspergillus niger are two major opportunistic fungal pathogens. Our results show that these fungi have high levels of both type I and type II topoisomerases (with… CONTINUE READING

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