DNA topoisomerases: structure, function, and mechanism.

@article{Champoux2001DNATS,
  title={DNA topoisomerases: structure, function, and mechanism.},
  author={J. Champoux},
  journal={Annual review of biochemistry},
  year={2001},
  volume={70},
  pages={
          369-413
        }
}
  • J. Champoux
  • Published 2001
  • Biology, Medicine
  • Annual review of biochemistry
    • DNA topoisomerases solve the topological problems associated with DNA replication, transcription, recombination, and chromatin remodeling by introducing temporary single- or double-strand breaks in the DNA. In addition, these enzymes fine-tune the steady-state level of DNA supercoiling both to facilitate protein interactions with the DNA and to prevent excessive supercoiling that is deleterious. In recent years, the crystal structures of a number of topoisomerase fragments, representing nearly… CONTINUE READING
    View PDF
    Top 3 of 2,083 Citations
    A universal type IA topoisomerase fold.
    M. Duguet, M. Serre, C. Bouthier de la TourJournal of molecular biology2006
    15
    Crystal structure of an intact type II DNA topoisomerase: insights into DNA transfer mechanisms.
    M. Graille, Lionel Cladière, … H. van TilbeurghStructure2008
    43
    Human DNA Topoisomerase I: Structure, Enzymology and Biology
    J. Champoux2012
    2

    Paper Mentions

    BLOG POST
    Exploiting DNA packaging
    Mapping Ignorance
    21 May 2018
    INTERVENTIONAL CLINICAL TRIAL
    Indenoisoquinoline LMP400 for Advanced Solid Tumors and Lymphomas
    Background: - Indenoisoquinoline LMP400 is an experimental cancer treatment drug. It damages DNA in tumor cells. Tumor cells with damaged DNA may die, resulting in cell death… Expand
    ConditionsLymphoma, Neoplasm
    InterventionDrug
    National Institutes of Health Clinical Center (CC)
    February 2013 - October 2017
    INTERVENTIONAL CLINICAL TRIAL
    A Phase I Study of Indenoisoquinolines LMP400 and LMP776 in Adults With Relapsed Solid Tumors and Lymphomas
    Background: - Indenoisoquinolines are experimental cancer treatment drugs that damage the DNA in cells, resulting in cell death. Researchers have been studying these drugs… Expand
    ConditionsLymphoma, Neoplasms
    InterventionDrug
    National Institutes of Health Clinical Center (CC)
    January 2010 - June 2017
    2,083 Citations
    Fields of Study

    Fields of Study

    Citation Type

    Citation Type

    A universal type IA topoisomerase fold.
    15
    Crystal structure of an intact type II DNA topoisomerase: insights into DNA transfer mechanisms.
    43
    Human DNA Topoisomerase I: Structure, Enzymology and Biology
    2
    DNA Topoisomerases: Type II
    24
    Topoisomerase II: a fitted mechanism for the chromatin landscape
    77
    Topoisomerases and site-specific recombinases: similarities in structure and mechanism
    26
    Topoisomerase Inhibitors and Types of Them
    4
    Topoisomerase IB: a relaxing enzyme for stressed DNA
    Type IA DNA topoisomerases: Strictly one step at a time
    18
    Analysis of the eukaryotic topoisomerase II DNA gate: a single-molecule FRET and structural perspective
    22

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 337 REFERENCES
    The structure of Escherichia coli DNA topoisomerase III.
    65
    Protein–nucleotide interactions in E. coli DNA topoisomerase I
    26
    A 26 kDa yeast DNA topoisomerase I fragment: crystallographic structure and mechanistic implications.
    26
    Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.
    732
    Structural insights into the function of type IB topoisomerases.
    55
    Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA.
    124
    An atypical topoisomerase II from archaea with implications for meiotic recombination
    764
    Structure and conformational changes of DNA topoisomerase II visualized by electron microscopy.
    46
    Structure and function of an archaeal topoisomerase VI subunit with homology to the meiotic recombination factor Spo11
    136
    Catalytic mechanism of DNA topoisomerase IB.
    143