DNA topoisomerases: structure, function, and mechanism.
@article{Champoux2001DNATS, title={DNA topoisomerases: structure, function, and mechanism.}, author={J. Champoux}, journal={Annual review of biochemistry}, year={2001}, volume={70}, pages={ 369-413 } }
DNA topoisomerases solve the topological problems associated with DNA replication, transcription, recombination, and chromatin remodeling by introducing temporary single- or double-strand breaks in the DNA. In addition, these enzymes fine-tune the steady-state level of DNA supercoiling both to facilitate protein interactions with the DNA and to prevent excessive supercoiling that is deleterious. In recent years, the crystal structures of a number of topoisomerase fragments, representing nearly… CONTINUE READING
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