DNA topoisomerases: structure, function, and mechanism.

  title={DNA topoisomerases: structure, function, and mechanism.},
  author={James J. Champoux},
  journal={Annual review of biochemistry},
  • J. Champoux
  • Published 2001
  • Biology
  • Annual review of biochemistry
DNA topoisomerases solve the topological problems associated with DNA replication, transcription, recombination, and chromatin remodeling by introducing temporary single- or double-strand breaks in the DNA. In addition, these enzymes fine-tune the steady-state level of DNA supercoiling both to facilitate protein interactions with the DNA and to prevent excessive supercoiling that is deleterious. In recent years, the crystal structures of a number of topoisomerase fragments, representing nearly… 

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