DNA topoisomerase II in therapy-related acute promyelocytic leukemia.

  title={DNA topoisomerase II in therapy-related acute promyelocytic leukemia.},
  author={Anita R Mistry and Carolyn A. Felix and Ryan J Whitmarsh and Annabel Mason and Andreas Reiter and Bruno Cassinat and Anne Parry and Christoph Walz and Joseph Wiemels and Mark R. Segal and Lionel Ad{\`e}s and Ian A Blair and Neil Osheroff and Andrew Peniket and Marina Lafage-Pochitaloff and Nicholas C P Cross and Christine Chomienne and E. Solomon and Pierre Fenaux and David J Grimwade},
  journal={The New England journal of medicine},
  volume={352 15},
BACKGROUND Chromosomal translocations leading to chimeric oncoproteins are important in leukemogenesis, but how they form is unclear. We studied acute promyelocytic leukemia (APL) with the t(15;17) translocation that developed after treatment of breast or laryngeal cancer with chemotherapeutic agents that poison topoisomerase II. METHODS We used long-range polymerase chain reaction and sequence analysis to characterize t(15;17) genomic breakpoints in therapy-related APL. To determine whether… CONTINUE READING