DNA topoisomerase I in the mouse central nervous system: Age and sex dependence.

@article{Plaschkes2005DNATI,
  title={DNA topoisomerase I in the mouse central nervous system: Age and sex dependence.},
  author={Inbar Plaschkes and F William Silverman and Esther Priel},
  journal={The Journal of comparative neurology},
  year={2005},
  volume={493 3},
  pages={357-69}
}
Topoisomerase I (topo I) is a nuclear enzyme responsible for the topological state of DNA and therefore participates in most DNA transactions, particularly in transcription. Topo I, a ubiquitous enzyme, was identified and characterized in various cell types and tissues; however, the characterization of topo I in the intact central nervous system was not performed. Here we investigated, for the first time, the activity, level, and distribution pattern of topo I in the various selected brain… CONTINUE READING

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